Here are some possibly helpful references for you and/or your friend:
Michelot D, Melendez-Howell LM. Amanita muscaria: chemistry, biology, toxicology, and ethnomycology. Mycol Res. 2003 Feb;107(Pt 2):131-46 -
Medline (PMID=12747324)
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Rhodium's page
(
https://www.thevespiary.org/rhodium/Rhodium/pdf/amanita.muscaria.review.pdf)
Professor Buzz. The synthesis of muscimol -
Rhodium's page
(
https://www.thevespiary.org/rhodium/Rhodium/chemistry/muscimole.html)
Davis DP, Williams SR. Amanita muscaria. J Emerg Med. 1999 Jul-Aug;17(4):739 -
Medline (PMID=10431970)
Becker H. Components of Amanita muscaria. Pharm Unserer Zeit. 1983 Jul;12(4):111-8 -
Medline (PMID=6684299)
Chilton WS, Ott J. Toxic metabolites of Amanita pantherina, A. cothurnata, A. muscaria and other Amanita species.
Lloydia. 1976 Mar-Jun;39(2-3):150-7 -
Medline (PMID=985999)
Scotti de Carolis A, Lipparini F, Longo VG. Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria. Psychopharmacologia. 1969;15(3):186-95 -
Medline (PMID=5389124)
Eugster CH. Chemistry of active materials from the fly agaric (Amanita muscaria). Fortschr Chem Org Naturst. 1969;27:261-321 -
Medline (PMID=4907242)
Eugster CH. Isolation, structure, and syntheses of central-active compounds from Amanita muscaria (L. ex Fr.) hooker. Psychopharmacol Bull. 1967 Dec;4(3):18-9 -
Medline (PMID=5629522)
Bowden K, Drysdale AC, Mogey GA. Constituents of Amanita muscaria. Nature. 1965 Jun 26;206(991):1359-60 -
Medline (PMID=5891274)
Eugster CH, Muller GF, Good R. The active ingredients from Amanita muscaria: ibotenic acid and muscazone. Tetrahedron Lett. 1965 Jun;23:1813-5 -
Medline (PMID=5891631)
Bowden K, Drysdale AC. A novel constituent of Amanita muscaria. Tetrahedron Lett. 1965 Mar;12:727-8 -
Medline (PMID=14291871)
Takemoto T, Nakajima T, Sakuma R. Isolation of a flycidal constituent "IBOTENIC ACID" from Amanita muscaria and A. pantherina. Yakugaku Zasshi. 1964 Dec;84:1233-4 -
Medline (PMID=14266561)
Gonmori K, Yoshioka N. The examination of mushroom poisonings at Akita University. Leg Med (Tokyo). 2003 Mar;5 Suppl 1:S83-6 -
Medline (PMID=12935559)
- DOI:
10.1016/S1344-6223(02)00127-X
Maurer HH, Schmitt CJ, Weber AA, Kraemer T. Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins alpha- and beta-amanitin in urine after immunoaffinity extraction. J Chromatogr B Biomed Sci Appl. 2000 Oct 1;748(1):125-35 -
Montanini S, Sinardi D, Pratico C, Sinardi AU, Trimarchi G. Use of acetylcysteine as the life-saving antidote in Amanita phalloides (death cap) poisoning. Case report on 11 patients. Arzneimittelforschung. 1999 Dec;49(12):1044-7 -
Medline (PMID=10635453)
Jaeger A, Jehl F, Flesch F, Sauder P, Kopferschmitt J. Kinetics of amatoxins in human poisoning: therapeutic implications. J Toxicol Clin Toxicol. 1993;31(1):63-80 - [pubmed]8433416[/pubmed]
Here are some abstracts from PubMed:
Hohn H, Schoenemann J. Cholinergic syndrome with unconsciousness in amanita poisoning. Dtsch Med Wochenschr. 2000 Nov 10;125(45):1366-8 -
ABSTRACT: HISTORY AND ADMISSION FINDINGS: A 41-year-old patient was found in his flat in a state of coma. After emergency treatment his vital signs were stable and he was transferred to an acute hospital with possible cannabis intoxication. The patient, a hobby gardener, was previously well and had an adversion to the use of any chemical substances. The main symptom showed a cholinergic syndrome with deep coma. We assumed plant ingestion because of the clinical picture and history. INVESTIGATIONS: The laboratory results were within normal limits apart from a slight rise of the serum creatinine kinase level. The electrocardiogram showed a bradycardia. A drug-screening could not be performed. TREATMENT AND COURSE: The differential diagnosis of plant alkaloids or mushroom toxins were considered due to possible plant ingestion and a cholinergic syndrome. Later the toadstool (Amanita muscaria) was found. After treatment oft the cholinergic syndrome with high doses of atropine primary poison elimination was performed. 24 hours later the patient awoke from his coma. Visual hallucinations persisted for a few days. No organic damage due to the intoxication was found. CONCLUSION: Toxic mushroom ingestion can produce a variety of clinical pictures. Most commonly an anticholinergic syndrome is found, but this was not the case in this patient. The effect of the poison depends on the amount and the preparation, so that no reliable outcome prediction can be made. The drug "poisonous mushroom" is legal and hallucinogenic substances are trendy. As a result clinical signs like those described here will have to be expected in the future.