Alrighty then, I guess the Bees that could help are just too played out on the Codeine>Oxy synth to help. What are yeh gonna do ??.
That’s OK I figured it out all by myself. However it would have been nice if one of these learned Sages had taken the time to answer…………like I said what are yeh gonna do ??.
Lets see if a riddle interests the brain-trust.
OK
I have read/surfed and browsed my eyes out and came up with what appears to the untrained eye to be a double standard in some Synths that Rho has posted on his site. Here are the pertinent URL’s
https://www.thevespiary.org/rhodium/Rhodium/chemistry/hydrocodone.html
%3Bhttps%3A//www.rhodium.ws/chemistry/dihydromorphinones.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/hydrocodone.html
%3Bhttps%3A//www.rhodium.ws/chemistry/dihydromorphinones.html)
The first link calls for 2 fairly elaborate steps to reach dihydrocodeinone.
The second link calls for 1 very easy step to reach dihydrocodeinone, IE: Codeine Freebase+ dil hcl+PD/C+1hr reflux= dihydrocodeinone
Dihydrocodeinone by definition is the active narcotic in Vicodin. Correct ??? (1. See attachment below)
So learned ones my question to you is what is the best synth to use ?? Will the second one convert Codeine Freebase to dihydrocodeinone AKA Vicodin ??
Hows this laid out LabTop ??
Merck
Monograph number: 4826
Title: Hydrocodone
CAS Registry number: [125-29-1]
CA name(s): 4,5-Epoxy-3-methoxy-17-methylmorphinan-6-one;
Additional name(s): dihydrocodeinone;
Trade names(s): Bekadid; Dicodid (Knoll).
Molecular formula: C18H21NO3
Molecular weight: 299.37
Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%.
Literature references: Prepn by hydrogenation of codeinone: Mannich, Lowenheim, Arch. Pharm. 258, 295 (1920); by oxidation of dihydrocodeine, Ger. pat. 415,097 (1925 to E. Merck), Frdl. 15, 1518 (1925-1927); by catalytic rearrangement of codeine: Ger. pat. 623,821. Industrial prepn from dihydrocodeine: K. Pfister, M. Tishler, U.S. pat. 2,715,626 (1955 to Merck Co.). Pharmacology and toxicity data: N. B. Eddy, J. G. Reid, J. Pharmacol. Exp. Ther. 52, 468 (1934). Brief description: A. Stein, Pharmazie 10, 180 (1955). Review: Small, Lutz, "Chemistry of the Opium Alkaloids," Suppl. No. 103, Public Health Reports, Washington (1932).
Properties: Prisms from alcohol, mp 198 deg. Sol in alcohol, dil acids. Insol in water. uv max: 280 nm (.epsilon. 1310). LD50 s.c. in mice: 85.7 mg/kg (Eddy, Reid).
Melting point: 198
UV Maxima: 280
Caution: May be habit forming. This is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1 and 1308.12 (1995).
Derivative: Hydrochloride monohydrate
Molecular formula: C18H21NO3.HCl.H2O
Properties: crystals, mp 185-186 deg dec. [.alpha.]D27 -130 deg (c = 2.877). Very sol in water.
Melting point: 185-186
Rotation: -130
Derivative: Bitartrate hemipentahydrate
CAS Registry number: [34195-34-1]
Trade name(s): Calmodid, Codinovo, Duodin, Kolikodal, Orthoxycol, Mercodinone, Synkonin, Norgan, Hydrokon
Molecular formula: C18H21NO3.C4H6O6.2H2O
Properties: Needles, mp 118-128 deg. One gram dissolves in 16 ml water, in 150 g 95% ethanol. Almost insol in ether, chloroform. pH of a 2% aq soln about 3.6.
Melting point: 118-128
Derivative: Hydriodide
Molecular formula: C18H21NO3.HI
Properties: mp 219-220 deg.
Melting point: 219-220
Derivative: Methiodide
Molecular formula: C18H21NO3.CH3I
Properties: mp 250-255 deg.
Melting point: 250-255
THERAP CAT: Analgesic (narcotic); antitussive.
Thanks as always In advance for all your help
Leave the gun..........take the Canoli.
US5847142
although the two step - 7-8 reduction followed by oppenhaurer oxidation is probably the only feasable route to hydrocodone/dilaudid from codeine and morphine for the cland chemist this patent is interesting. It is one step simultaneous hydrogenation/dehydrogenation similar to the one archived at rhodiums based on the German patent https://www.thevespiary.org/rhodium/Rhodium/chemistry/dihydromorphinones.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/dihydromorphinones.html)
.
it is interesting that they also could not replicate the claimed yields with palladium black.
Catalytic rearrangement of morphine has been described using palladium black. It is not possible, however, to carry out this process on a large scale that would be suitable for manufacturing since the procedure affords 30-35% of the undesired o-desmethylthebainone along with the desired product. Isolation of the pure product is very tedious and requires extensive purification.
The present inventors have now found a new one-step route to hydrocodone and hydromorphone giving greater than 80% yield requiring minimal purification by simple methods.
the process uses organometallic complexes as catalyst. the rearrangement simultaneously oxidises the hydroxy to the keto group and also saturates the cyclohexene ring.
Bulldog, listen to Rhodium and Ritter's advice since they are the experienced chemists here and do it in two steps.
here is the link for the two-step conversion https://www.thevespiary.org/rhodium/Rhodium/chemistry/hydrocodone.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/hydrocodone.html)