Carbromal(Uradal, Adalin)
1 mole of
?-bromo-?-ethyl butyryl bromide is mixed with dry urea(1 mole) and heated on a steam bath for several hours. Precautions must be taken to keep steam and atmospheric H
2O from the reaction vessel. Cool, allow to solidify, wash with H
2O, and recrystallize from alcohol. Dose: (sedative) 300 to 500mg, (hypnotic) 700 to 950mg, mp 116-118°C. This drug is less potent than the barbiturates, but it is less toxic, extremely well tolerated, has a wide margin of safety, and acts rapidly.
Bromural(Bromovaletone)
This is made the same way that carbromal is made, except that the intermediate is
?-bromo-isovaleryl bromide. The 1 to 1 molar ratio and everything else remains unchanged Yields colorless crystals, mp: 147-149°C. This is a rapid-action, short-duration hypnotic. It is well tolerated and has a low toxicity. Dose: 300-600mg.
Reference: “Recreational Drugs” by Professor Buzz
These synths are so easy that even Professor Buzz can’t fuck them up!
Are either bromo-intermediates easily obtainable? I can’t find my merck index CD, and a patent search at
http://ch.espacenet.com/espacenet/ch/en/e_net.htm
didn’t turn-up dick, so I’m wondering how they’re made, do they have any synonyms, what their properties are? Are there other ureides or analogs that could possibly have sedative effects? Peace!