Polyethylene glycol as support and phase transfer catalyst in aqueous palladium-catalyzed cross-coupling reactions
Chemical Journal on Internet, Vol 3, No 8, p 39 (2001)
http://www.chemistrymag.org/cji/2001/038039ne.htm
Abstract:
Excellent yields and purity were obtained in the aqueous palladium-catalyzed Suzuki, Sonogashira, Still and Heck reactions under mild conditions using polyethylene glycol (PEG) as soluble polymeric support and phase transfer catalyst as well.
Keywords liquid-phase synthesis, polyethylene glycol, cross-coupling reaction, phase transfer catalyst, palladium catalyst.
In summary, we have shown a liquid-phase methodology for the palladium-catalyzed cross-coupling reactions in water on soluble support of PEG 4000. The reaction not only provide corresponding products in excellent yields and purity, but also were carried out under mild conditions due to the contribution of PEG bound substrates as PTC. It is potential for these reactions to be assumed for the combinatorial and parallel synthesis on the soluble polymeric support.
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