Author Topic: Uses of Vanilline  (Read 1986 times)

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Xicori

  • Guest
Uses of Vanilline
« on: June 23, 2004, 03:04:00 PM »
High Bees!

The topic about using vanilline as a precoursor was often discussed here at the hive, and many documents can be found at rhodium.ws.

...what is missing is a collection of routes from vanilline to several PEA and Amphetamine derivates. Swim used the FSE, and came up with the routes shown in the picture below:



It is possible (even very likely) that my searches didnt cover all the possibilities to psychoactive material. So please add other routes that may be considered!

Another question is, if the DMS (for example for methylating the 5-OH-Vanilline to 3,4,5-TMBA) can be substituted for MethylTosylate? Would be way nicer to work with! ...Trimethylphosphate should work, but it´s also very toxic, and not as available as the Tosylate ester.

References:

[1]

Post 297806

(uemura: "How to prepare hydroxyvanillin", Methods Discourse)

[2]

Post 297806

(uemura: "How to prepare hydroxyvanillin", Methods Discourse)
,

https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.mescaline.html


[3]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.mescaline.html

,

https://www.thevespiary.org/rhodium/Rhodium/chemistry/345-tmb.html


[4] Pihkal #25:

http://www.erowid.org/library/books_online/pihkal/pihkal025.shtml


[5]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/methylenation.html


[6]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/methylenation.html


[7]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.mescaline.html


[8]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/tma2.vanillin.html



DMS methylations are standard, and procedures are given on many of the above links.

Edit: references added

Best wishes,
xicori

Rhodium

  • Guest
What are your references?
« Reply #1 on: June 23, 2004, 05:02:00 PM »
Please add links to the respective procedures so that your overview becomes more useful.


Captain_America

  • Guest
good work
« Reply #2 on: July 18, 2004, 01:36:00 AM »
Another question is, if the DMS (for example for methylating the 5-OH-Vanilline to 3,4,5-TMBA) can be substituted for MethylTosylate? Would be way nicer to work with! ...Trimethylphosphate should work, but it´s also very toxic, and not as available as the Tosylate ester.

Yes, see:

Post 458188

(Lego: "Some alkylations with alkyl tosylates, Pt. 1", Novel Discourse)

Post 458190 (missing)

(Lego: "Some alkylations with alkyl tosylates, Pt. 2", Novel Discourse)

Post 458191 (missing)

(Lego: "Some alkylations with alkyl tosylates, Pt. 3", Novel Discourse)


But I think it is easier to make alkylhalides.