Post 511284 (https://www.thevespiary.org/talk/index.php?topic=6626.msg51128400#msg51128400)
(lugh: "5-bromosalicylaldehyde", Chemistry Discourse), but "deutsche sprache" is kinda like ancient hieroglyphics for me. I briefly understand what they say and as far as I can see it is a standard Br2/GAA bromination. One could therefore easily use a procedure for brominating vanillin as an example. I believe (or should I say, hope) that hydroxyl group would push the bromine to the para position, so the main product would be 5-bromo-2-hydroxybenzaldehyde (5-Br salicylaldehyde).Patent US4551558 (http://l2.espacenet.com/dips/viewer?PN=US4551558&CY=gb&LG=en&DB=EPD)
- Bromination of substituted benzaldehydeshttps://www.thevespiary.org/rhodium/Rhodium/chemistry/345-tmb.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/345-tmb.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/arylhalide.methanolysis.cu-etoac.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/arylhalide.methanolysis.cu-etoac.html)
Post 503332 (https://www.thevespiary.org/talk/index.php?topic=6626.msg50333200#msg50333200)
(Rhodium: "Methoxylation of Aryl bromides cat. by Cu(II)-CO2", Chemistry Discourse)Post 511008 (https://www.thevespiary.org/talk/index.php?topic=6626.msg51100800#msg51100800)
(demorol: "Methoxylation of various aryl bromides", Chemistry Discourse)Post 477850 (https://www.thevespiary.org/talk/index.php?topic=6626.msg47785000#msg47785000)
(Rhodium: "ArBr --NaOMe/Cu(I)--> ArOMe", Chemistry Discourse)Post 257912 (https://www.thevespiary.org/talk/index.php?topic=11282.msg25791200#msg25791200)
(Antoncho: "Alkali metal alkoxides: finally, OTC!", Novel Discourse)Post 512006 (https://www.thevespiary.org/talk/index.php?topic=10688.msg51200600#msg51200600)
(Nicodem: "The patents work", Newbee Forum)Post 348592 (https://www.thevespiary.org/talk/index.php?topic=7674.msg34859200#msg34859200)
(Antoncho: "Methyl iodide methylation of 2-OH-5-MeO-BA.", Chemistry Discourse)Post 511704 (https://www.thevespiary.org/talk/index.php?topic=9352.msg51170400#msg51170400)
(Aurelius: "O-Alkylation Agents: Synthesis and Use", Methods Discourse)https://www.thevespiary.org/rhodium/Rhodium/chemistry/me3po4.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/me3po4.html)
- Trimethyl phosphate alkylation of phenolic aldehydesPost 532051 (https://www.thevespiary.org/talk/index.php?topic=9336.msg53205100#msg53205100)
(Captain_America: "5-bromo-2-methoxybenzaldehyde", Methods Discourse)Post 532056 (https://www.thevespiary.org/talk/index.php?topic=9336.msg53205600#msg53205600)
(amine: "Bromination of Electron Rich Benzaldehydes", Methods Discourse)Post 459979 (https://www.thevespiary.org/talk/index.php?topic=6431.msg45997900#msg45997900)
(demorol: "High-Yielding Halogenations using Halosuccinimides", Chemistry Discourse)