The Vespiary

The Hive => Newbee Forum => Topic started by: marc562 on March 01, 2003, 05:55:00 AM

Title: 1-dimethylamino-2-propanol-HOW?
Post by: marc562 on March 01, 2003, 05:55:00 AM

It says "and if this too is unavailable,it can be synthezized easily by the Eschweiler-Clarke methylation(15)of the very basic building block 1-amino-2-propanol,using formaldehyde and formic acid.I'ev spent a lot of time looking for this step,but can't find it.I know it's there and that I probably looking for it with the wrong wording.Can someone point me in the proper direction? Thank You :P

Title: Eschweiler-Clarke methylation
Post by: Rhodium on March 01, 2003, 12:43:00 PM

A search for "Eschweiler" gave 25 hits, among others the following, using either formaldehyde or paraformaldehyde:

Post 401843 (https://www.thevespiary.org/talk/index.php?topic=12066.msg40184300#msg40184300)

(Antoncho: "The easiest PhCOOH -> PhCHO reduction yet!", Novel Discourse)

Post 290447 (https://www.thevespiary.org/talk/index.php?topic=13151.msg29044700#msg29044700)

(Z_Hound: "Methylation: Eschweiler-Clark", Tryptamine Chemistry)