Author Topic: From Pepper to MDA experiments  (Read 8234 times)

0 Members and 1 Guest are viewing this topic.

tmpvar

  • Guest
Very depressing.... let me clarify, using...
« Reply #40 on: May 06, 2003, 10:27:00 AM »
Very depressing.... let me clarify, using  nitromethane/cyclohexylamine to do Piperonal->MDP2P will not work?  I dont know if it helps, but Ive read that you can substitute cyclohexylamine with methylamine... is this reaction still undooable?

Thank you for your time!

SPISSHAK

  • Guest
you will get a nitro styrene
« Reply #41 on: May 06, 2003, 11:34:00 AM »
not a nitro-propene, if you converted to aldoxime and hydrolized a nitro-styrene you will get MDPAA methylenedioxyl-phenyl-acetaldehyde, not the methyl ketone.
Yes those amines will work in the condensation reaction.

Nick_J

  • Guest
MDP2P?
« Reply #42 on: May 06, 2003, 11:43:00 AM »
let me clarify, using nitromethane/cyclohexylamine to do Piperonal->MDP2P will not work?

Well, I'm still new to all this, I'm sure a more experienced bee will come along and tell you for certain soon...

But, I fail to see how that could form MDP2P, which as far as I'm aware is (methylenedioxyphenyl)propanone. Did you just get your abbreviations mixed up? I know that happens to me a lot  :( .

I drew a little diagram to illustrate the problem:

http://www.boomspeed.com/mrcool/NE_NM_Comparison.jpg




tmpvar

  • Guest
Oh..
« Reply #43 on: May 06, 2003, 12:13:00 PM »
Well its good that methylamine can be a replacement!

Ya, I think I was actually talking about nitroalkene.

I like the nitroethanol idea.. but I dont know whether the results can be reduced to MDA

Over and Out.

tmpvar

  • Guest
Sorry about the multiple posts..
« Reply #44 on: May 06, 2003, 12:26:00 PM »
I think that the nitroethanol idea will work acording to

https://www.thevespiary.org/rhodium/Rhodium/chemistry/nitro2amine.zn-formate.html




"Aliphatic and aromatic nitro compounds are selectively and rapidly reduced to their corresponding amino derivatives in good yields using Ammonium Formate and commercial Zinc dust. This system is found to be compatible with several sensitive functionalities including halogens, -OH, -OCH3, -CHO, -COCH3, COC6H5, -COOH, -CO2C6H5, -CONH2, -CN, -CH:CHCOOH, -NHCOCH3. The reduction can be carried out not only with HCOONH4 but also with HCOOH. "

Hope it helps

SPISSHAK

  • Guest
I don't think it will work
« Reply #45 on: May 06, 2003, 01:36:00 PM »
if you use nitro ethanol.
That merely says you can reduce the nitro group without affecting other functional groups using that system.
You may end up with the amine or oxime but you will probably have a terminal alcohol grouping on the end of the propyl chain.
They aren't so easily reduced.

tmpvar

  • Guest
Hrm...
« Reply #46 on: May 06, 2003, 02:23:00 PM »
So the procedure in (

https://www.thevespiary.org/rhodium/Rhodium/chemistry/nitro2amine.zn-formate.html

) wont remove the  terminal alcohol grouping?

If this is not possible, do you know of any other ways to go from piperonal to MDA without using nitroethane? or other watched precursors?

Thank you for you time!

Rhodium

  • Guest
Unfortunately not
« Reply #47 on: May 06, 2003, 06:19:00 PM »
No, it will not remove the terminal alcohol grouping, for that you need drastic conditions like in these docs:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/amphetamine.phenylalanine.html


https://www.thevespiary.org/rhodium/Rhodium/chemistry/amph.phenylalanine.html


hCiLdOdUeDn

  • Guest
Nitroethane the easy way.
« Reply #48 on: May 06, 2003, 07:07:00 PM »
If you cannot find nitroethane (its hard to find in some places) I suggest synthesizing nitroethane using Sodium Ethyl Sulfate and Sodium Nitrite. Sodium Ethyl Sulfate can easily bee made and sodium nitrite is easily obtained. Yields are OK so you can get a nice sum of nitroethane if you are working on the 1-2L scale.

If you dont want to go through the trouble of extracting piperine from pepper, there ARE suppliers selling bulk piperine for cheap.

tmpvar

  • Guest
Thanks
« Reply #49 on: May 06, 2003, 09:11:00 PM »
Thank you Rhodium and hCiLdOdUeDn!

hCiLdOdUeDn

  • Guest
Your Welcome!
« Reply #50 on: May 07, 2003, 09:49:00 PM »
Your Welcome!~

Good luck to you in the future!