The Vespiary

The Hive => Tryptamine Chemistry => Topic started by: trade_om on July 15, 2004, 05:46:00 AM

Title: 4-ho-tryptamine into 4-ho-dmt?
Post by: trade_om on July 15, 2004, 05:46:00 AM
Hello.
Is going from 4-Hydoxy-Tryptamine into 4-Hydroxy-DiMethylTryptamine possible via any of the routes used to go from tryptamine into dmt? as in this -

https://www.thevespiary.org/rhodium/Rhodium/chemistry/tryptamine2dmt.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/tryptamine2dmt.html)

?
Or is this completly impossible because the link between the HO molecule and the Carbon is too weak and will break when subjected to this kind of synthesis route?
Title: kjiuyh
Post by: hest on July 15, 2004, 06:14:00 AM

4-Hydoxy-Tryptamine into 4-Hydroxy-Tryptamine

huu ???
But yess, iff you have some 4-OH-tryptamine (lucky bastard) you can use the method in the link.

Title: They use the benzyl protected 4-OH-indole
Post by: Lego on July 15, 2004, 07:05:00 AM

Post 127141 (https://www.thevespiary.org/talk/index.php?topic=13241.msg12714100#msg12714100)

(ejlmp: "Psilocin in 5 steps", Tryptamine Chemistry)

By which method you want to synthesize the 4-hydroxy-indole?

Title: I guess that the one who will choose to follow
Post by: trade_om on July 15, 2004, 08:40:00 AM
I guess that the one who will choose to follow this reaction would like to purchase the 4-hydroxyindloe from a supplier.
Title: Whoops
Post by: Lego on July 15, 2004, 09:41:00 AM
Sorry, 4-hydroxy-tryptamine was meant of course....

Purchasing 4-hydroxy-indole/tryptamine is no good idea (in Lego's opinion) for two reasons:
1) the price
2) it is quite suspicious


Try unsubstituted tryptamine first....

Title: I wonder what would be the effects of 6-ho-DMT
Post by: trade_om on July 15, 2004, 09:55:00 AM
I wonder what would be the effects of 6-ho-DMT if this compound was ever synthesized...
Title: Hard to focus on one topic at a time, eh? ;-)
Post by: Rhodium on July 15, 2004, 12:33:00 PM

"It is pretty generally accepted that 6-HO-DMT is inactive. I am not too surprised. There are so few things with open and exposed hydroxyl groups that succeed in making it through the lipid barriers to the brain."


Alexander Shulgin in

TiHKAL (http://www.erowid.org/library/books_online/tihkal/tihkal03.shtml#6-HO-DMT)

(http://www.erowid.org/library/books_online/tihkal/tihkal03.shtml#6-HO-DMT)

Title: Beside that 4-OH-tryptamine is quite ...
Post by: Lilienthal on July 15, 2004, 12:57:00 PM
Beside that 4-OH-tryptamine is quite sensitive, especially even under slightly basic conditions. You would want to protect the hydroxy first with an apropriate group.