The Vespiary

The Hive => Methods Discourse => Topic started by: SilverSurfer on December 05, 2003, 09:32:00 AM

Title: reduction of isonicotinic acid
Post by: SilverSurfer on December 05, 2003, 09:32:00 AM

Reffering to demerol synth


Why isnt the reduction of the isonicotinicacid step one,
instead reducing it before methylating

Is there recently a more practically way of reducing it?

(https://www.thevespiary.org/rhodium/Rhodium/chemistry/pethidine.html)

Title: why
Post by: Rhodium on December 05, 2003, 01:24:00 PM

N-Alkyl-pyridinium salts are more easily reduced than the plain pyridines.