After weeks in the lib. it seems to be the easyest way to cocaine:
2,5 dimethoxytetrahydrofuran to yield succinaldehyd
succinaldehyd, MeNH3Cl and beta-ketoglutaric anhydride to
yield d,l-2-Carbomethoxytropinone
d and l 2-Carbomethyxytropinone via the Tartrates
After NaBH4
and Benzoylation with Benoeacidanhydrid to yield (-)-cocaine
Does anyone have some proofs for this reaktion ? Why only d,l-2-carbomethoxytropinone builds and not d,l-4-carbomethoxytropinone ? Hmm ?