So the beta-methyl phenyl-(sec)butyl-N-methylamine, the amine located on the sec-butyl's ?-carbon.
This is isomeric with MBDB, the difference being the sec-butyl group, the second carbon where the sidechain branches, is in the guise of an ethyl grop in MBDB, here, its relocated to being
part of the linear section of the sidechain. IMO what will make any dramatic difference if there are any is the increase in sidechain length, which in MBDB, has the amine two carbons away from the phenyl ring, in this critter, its three. Similarly theres some steric bulk due to the branching. Less in the case of this thing, a carbon more, and closer to the N-methyl amine in MBDB, which is certainly going to influence binding. On the one hand theres going to bee, assuming the sec-butyl thingy can fit properly within the typical binding pocket at SERT, NET, DAT and whathaveye, there might well be more space if the binding pocket is small, resulting in easier binding, although Tsath' isn't well up to date on how MDxx bind with monoamine transporters on a functional group-aminoacid-of-transporters goes. Toady is conjecturing here totally, but its not impossible that lengthening the sidechain like is done in this compared with MBDB, he's thinking MAYBEE the result of fthat would be to simulate an amphetamine more closely than a phenethylamine, which if the increase in steric bulk where the sidechain branches doesn't stick out so much as in MBDB.
Considering the result of lengthening the alpha substituent from methyl to ethyl in amphetamine, to give phenisobutylamine results in a pretty dramatic loss in potency in terms of dopaminergic effects contrasted with amphetamine itself, toady thinks that the decrease in this case relative to MBDB can only be a good thing. The million-dollar question is, whats the
change from isobutyl to sec-butyl going to do.
Anyone good at receptor docking studies? if so, then it'd be fruitful IMO to compare binding at NET, SERT and DAT between MDMA, MBDB, the alpha-ethyl homolog of MDMA, and overlaiy each with this sec-butyl critter.