Trimethylorthoformate from chloroform with NaOH/MeOH ? It just looks like. No NaOMe needed.
Am I the only one that is unable to see more than the first page of this patent ?
(www.espacenet.com doesn't work for me, I get all my patents from www.depatisnet.de)
Patent JP000058225036AA (http://l2.espacenet.com/dips/viewer?PN=JP000058225036AA&CY=gb&LG=en&DB=EPD)
PURPOSE: The reaction mixture resulting from a reaction between methanol or ethanol, a caustic alkali and chloroform is combined with a specific solvent to effect almost quantitative extraction of the titled compound into the solvent.
CONSTITUTION: Methanol, or ethanol, a caustic alkali, preferably an alcoholic solution of sodium or potassium hydroxide, and chloroform are made to react and the resultant reaction mixture is combined with a solvent which is selected from aliphatic or aromatic hydrocarbons, ethers or their halogenated products, and is low in compatibility with water and capable of separating the product by distillation, in an amount of 1.0W1.5 times the volume of the product. Then, they are vigorously stirred at 20W35°C and separated by standing to effect extraction of the objective orthoformate into the organic solvent layer, while the alkali chloride goes in the aqueous layer. The above solvent can be added at the reaction stage except carbon tetrachloride.
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Ethyl (S)-2-(4-Tolylsulfonyloxy)propanoate (22): 4-Toluenesulfonyl chloride (6.0 g, 31.5 mmol) was added in portions to a solution of ethyl (S)-2-hydroxypropanoate (21) [2.5 g, 21.1 mmol; commercially available,[a]14 = -10° (neat); [a]20D = -24 (c = 8.59, CHCl32)] with vigorous stirring at - 20°C.
Well, TsCl was added to a solution of ethyl lactate. A solution in what? Most probably, the authors meant a solution in pyridine, since they treat the reaction mixture with ice - HCl, a step which would be illogical if the reaction is conducted in the absence of a base. With pyridine as the solvent/base it becomes a standard tosylation of an alcohol.
I'm pretty sure that without a base the reaction of TsCl with a secondary alcohol is very slow, and only traces of the product will be formed after several hours at room temperature.
In the post Post 417550 (https://www.thevespiary.org/talk/index.php?topic=11342.msg41755000#msg41755000)
(Antoncho: "Methyl tosylate: _finally_ , OTC!!!", Novel Discourse) methyl tosylate is made from TsCl - MeOH - conc. NaOH which form a biphasic system. The reaction takes place in the organic phase which contains almost no water, so the hydrolysis of TsCl is suppressed.
I don't know if there exists a PTC tosylation method compatible with esters.
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)
Bull.Chem.Soc.Jpn., 68,1.1995;297-300 K2CO3 / Me3N.HCl
preparation of 2-Propynyl p-Toluenesulfonate 2a
To a stirred suspension of propargyl alcohol (5.6 g, 0.1 mol) and K2CO3 (15.2 g, 0.12 mol) in MIBK (50 mL) was added Me3N.HCl (0.96 g, 0.01 mol) at 0-5°C. After 5 min, p-toluenesulfonyl chloride (20.97 g, 0.12 mol) in MIBK (50 mL) was added at 0-5°C for an hout. After the mixture was stirred for an hour, water (100 g) was added at 20°C. The separated water phase was back extracted with MIBK (20 mL) and the combined organic extracts were first washed with water, and then, saturated aquaeous NaCl, dried (Na2SO4), concentrated, and purified by column chromatography (hexane/EtOAc=10:1) giving 19.13 g (91%) of the sulfonate 2a.
MIBK = methyl isobutyl ketone
Here's some other alternatives to Py / Et3N :
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)
Bull.Chem.Soc.Jpn., 63,4.1990;1260-1262 NaOH / THF
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)
synthesis 1999,9;1633-1636 TMEDA / Me2N-(CH2)n-NMe2 n=3, n=4, n=6 ;; shitty scan but you get the idea.
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)
Synthesis - 1997;1433-1438 DABCO
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_imgs/djvu.gif)
Tetrahedron Lett., 42.2001;8781-8783 Ag2O / KI
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