The Vespiary

The Hive => Chemistry Discourse => Topic started by: Prometheuz on May 23, 2003, 06:02:00 AM

Title: Sensibility of mercapto-groups to reduction
Post by: Prometheuz on May 23, 2003, 06:02:00 AM

After studying this excellent post

Post 434950 (https://www.thevespiary.org/talk/index.php?topic=11546.msg43495000#msg43495000)

(Chimimanie: "On 2C-T-x precursors", Novel Discourse), I wondered if the mercapto-group (or whatever it's called.... My nomenclature-skills are a bit rusty) can stand reduction with LAH?
I recon normal condensation with nitromethane would behave just fine with the compound (Z)?
My knowledge about sulphur-containing compounds is rather limited...

Title: LAH
Post by: Chimimanie on May 23, 2003, 07:30:00 AM

Hi!  :)  thank you for your comments

Yes the 4-alkylthio groups are stable to LAH, its the way good doctor Shulgin use to synthetise the various 2-CT. (benzaldehyde ->  nitrostyrene --LAH--> amine)

see

http://www.erowid.org/library/books_online/pihkal/pihkal043.shtml (http://www.erowid.org/library/books_online/pihkal/pihkal043.shtml)

For others question, please use the appropriate thread

Post 434950 (https://www.thevespiary.org/talk/index.php?topic=11546.msg43495000#msg43495000)

(Chimimanie: "On 2C-T-x precursors", Novel Discourse)