Hi!
Swim is going to play around with some parafluoro-4-methylaminorex in the near future, to see what kind of potency and subjective effects this compound has. The starting material will be pure 4-fluorobenzaldehyde. As this is a little more expensive than plain benzaldehyde, swim would like some general suggestions on the route, so that the risk of failure is minimized.
4-fluorobenzaldehyde -> para-fluoro(phenylnitropropanol) via Henry rxn:Swim was thinking of following
this
(
https://www.thevespiary.org/rhodium/Rhodium/chemistry/phenyl-2-nitropropanol.html) route to the compound. The heavily substituted 2,4,5-benzaldehyde turned out to be very insoluble in methanol, and thus required higher temperatures. The Merck index, states that 4-fluorobenzaldehyde is soluble in the lighter alcohols and ethers. Thus a candidate for this route, could be a reaction run in cold methanol. Does this sound reasonable?
para-fluoro(phenylnitropropanol) -> para-fluoro(phenylaminoalcohol)This seems easy enough. Just a standard Zn/formic acid reductions. Any reason why this shouldn't be a breeze?
Formation of the oxazoline ringStandard cyanate route i suppose...
And finally doseThere has been some discussions in past post's about the supposed potency of this critter. Someone suggested on the basis of some animal studies that it
could be ultra potent, and some disagreed. Can any of you remember if they ever concluded anything. What kind of dose should be expected, and what would be a descent dose to test first? I don't suppose it dust-mask-all-the-time potent?
Thank you for you feedback!
Regards
Bandil