cocaine review

[politoxicomania]

After weeks in the lib. it seems to be the easyest way to cocaine:
2,5 dimethoxytetrahydrofuran to yield succinaldehyd
succinaldehyd, MeNH3Cl and beta-ketoglutaric anhydride to
yield d,l-2-Carbomethoxytropinone
d and l 2-Carbomethyxytropinone via the Tartrates
After NaBH4
and Benzoylation with Benoeacidanhydrid to yield (-)-cocaine
Does anyone have some proofs for this reaktion ? Why only d,l-2-carbomethoxytropinone builds and not d,l-4-carbomethoxytropinone ?  Hmm ?

[politoxicomania]

question solved

my yield of about 1 Mol (ca.300g) costs only 100€ exclusive Lab
are the columbians still cheaper ??

[Vitus_Verdegast]

Could you give the refs for your procedures?

[politoxicomania]

Very good refs are:

Ann. Chem. 111, 434 (1923)
J. Am. Chem. Soc. 101, 2435-42 (1979)
J. Org. Chem. 1389 (1957) Findlay
J. Het. Chem. 24, 19-21 (1987)

any questions?  

[roger2003]

And your synthesis yields 300 g of the natural (-)isomer  from the 8 possible isomers ?

[politoxicomania]

yes
it is the
(2R,3S)-3-Benzoyloxy-tropan-2-carbonacidmethylester

[politoxicomania]

sorry
have i mentioned
this is only theorie of the reported yields in the refs

[slappy]

my yield of about 1 Mol (ca.300g) costs only 100€ exclusive Lab are the columbians still cheaper ??

Ya, sounds great buddy! Let us know when you start your own cartel.

Looks like someone needs to learn some basic organic stereochemistry. The d,l-tartrate resolution only resolves enantiomers, not diastereomers. So you are still left with 4 of the possible 8 isomers at the end, and you lose 50% of you material along the way.

[roger2003]

And the "over all yield" from succindialdehyde is  about 10 %

[politoxicomania]

if there is someone who needs some lessons in organic chemistry  it wont be me .....
iv send the chief bee a procedure to (-)cocaine from wich u will see the yield of 10 % (roger is right)
is about 100€ per mol
looking forward for the public procedure at rhodium

to slappy: there are so many , many more intersting topics, and species who can give much more legal money and honer
im just wondering why  a very big german chemikal supplier, who produced cocaine in large quantities in the middle years of the last century wasnt be copied by anyone so far.
Sure u will need a factory with 10-20 co-workers to produce in lucrative quantities, but who want to be a second escoba? or mess with Merck.
ron