the Hive BB
Serious Chemistry Forum
Oxygenated Tryptamines w/ LSD Activity incorp a Chiral Pyridine Moiety
profile | register | preferences | faq | search
next newest topic | next oldest topic
Author Topic: Oxygenated Tryptamines w/ LSD Activity incorp a Chiral Pyridine Moiety
Acme
Member posted 12-07-1999 01:48 PM
--------------------------------------------------------------------------------
J. Med. Chem. 1999, 42, 4257
The paper reveals that this class of compounds (made from 5-MeO-bromo-indole lithium anion and N-methyl proline O-methyl ester, then reduce carbonyl) , are ten-fold less active than LSD, but have activity comparable to DOI. Speculate that the compounds may have LSD-like effect in man.
Slappy
Moderator posted 12-08-1999 05:49 AM
--------------------------------------------------------------------------------
Actually, its "...Chiral Pyrrolidine Moiety...". Anyway, it is a very interesting article. I believe Rhodium mentioned it a while ago.
Nemesis
Member posted 12-12-1999 04:05 PM
--------------------------------------------------------------------------------
I've also mentioned this same article in fact I was going to post the synthesis procedures mentioned there on DMT World:
<A HREF="
http://dmt.lycaeum.org/ncgi/Forum6/HTML/000217.html"%3B>%3BSubstituted
3-(N-methylpyrrolidin-2-ylmethyl)-indoles with LSD-like activity![/url]
Check out some of my other posts, too!
-Nemesis
Acme
Member posted 12-13-1999 01:58 PM
--------------------------------------------------------------------------------
Sorry about the pyridine mistake, fellow-bees.
Slappy
Moderator posted 12-13-1999 11:32 PM
--------------------------------------------------------------------------------
Simple mistake, no need to apologize.
All times are CT (US)
next newest topic | next oldest topic
Administrative Options: Close Topic | Archive/Move | Delete Topic
Hop to: Select a Forum or ArchiveList of Forums:General DiscussionAcquisition DiscourseChemistry DiscourseMethods DiscourseNovel DiscourseCrystal MethSerious Chemistry ForumThe Hive CouchSerious Tryptamine DiscourseAdmin Chill-out TentList of Archives:Couch ArchivesClassics!Law and OrderThe litter box.misc. PEAs
Contact Us | the Hive
Powered by: Ultimate Bulletin Board, Version 5.39a
© Infopop Corporation (formerly Madrona Park, Inc.), 1998 - 1999.