Post 364288 (https://www.thevespiary.org/talk/index.php?topic=6911.msg36428800#msg36428800)
(Rhodium: "GABA -> GBL + GHB", Chemistry Discourse), Rhodium mentions succinic acid monomethyl ester giving a 90% yield with NaBH4 in H2O. Would this be a relatively straight forward reaction to do? Just add excess reducing agent slowly, then purify out final product?http://www.peacehealth.org/kbase/nord/nord1113.htm (http://www.peacehealth.org/kbase/nord/nord1113.htm)
)Swim found that a genetic disorder causing a deficiency of the enzyme Succinic semialdehyde dehydrogenase (SSADH) "leads to abnormal accumulation of the compound succinic semialdehyde, which is reduced or converted to 4-hydroxybutyric acid"
The condition is called GHB aciduria and it's not known whether or not the symptoms are due to increased plasma levels of GHB or of increased plasma levels of GHB are the result.
Could you simply just consume this compound and have it elevate GHB levels in your body?
It's probably possible with enough NADH in the body.
People missing the enzyme suffer seizures and other neurological problems, but that might be due to an excessive, long term build up of the GHB.
Again, it's not known if the excess GHB is a cause of the condition or simply an effect of it.