Post 410862 (https://www.thevespiary.org/talk/index.php?topic=9819.msg41086200#msg41086200)
(Megatherium: "Very interesting. Then, in US patent 2765315 a", Methods Discourse) and the other posts in this thread). I wouldn't recommend acylation of the piperidinol (after reaction of PhLi with the piperidone).Taking deprenyl will inhibit a large number of MAO-B enzymes, and therefore lower the MAO-B activity throughout the body, but you will never ever completely shut it down, and as long as it is still the least functional, MPTP will be toxic.
Dosages of Deprenyl 10mg/day inhibits CNS MAO-B about 90%, very litle MAO-B is found outside of the CNS. While what you have said is techinically true, studies using MPP+ and equivalent human normal Deprenyl dosgaes have failed to detect any evidence of neurotoxicity in animals. This is not to say that the same would hold true in humans, but given the rather extensive volume of research conducted with Deprenyl this would seem to be a very high probability. Not that a person should gamble their dopaminergic neurons on something with a "very high probability"...
Furthermore, development of Parkinson's Disease in cigarette smokers, who have extremely diminished MAO-B activity compared to non-smokers is virtually non-existant. It is theorized that overactive MAO-B or TH is probably largely to blame for the development of PD in that excessive breakdown of DA produces hydroxyl and superoxide radicals which inflict the same type of neuronal cell damage as MPP+, albeit in a slower way.
Finally, I wasn't suggesting that a person actually attempt to use Deprenyl for neuroprotection aganist MPP+, it was more a tongue and cheek suggestion that messing with these types of compounds is best left to those with the knowledge, experience and equipment to safely deal with them. This is why I added my disclaimer regarding Deprenyl and meperidine, this combination is absolutely contraindicated.
https://www.thevespiary.org/rhodium/Rhodium/pdf/flash.chromatography.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/flash.chromatography.pdf)
TLC Mesh Column Chromatography (https://www.thevespiary.org/rhodium/Rhodium/pdf/tlc.mesh.column.chromatography.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/tlc.mesh.column.chromatography.pdf)