O Thou, mighty elephant headed god of experience, clearer of obstacles and beneficent guide of the ignorant and cocky: What do I need to know to safely and productively upscale a reaction of this nature (say, 300x) ?
Would this reaction work with acetone instead of formaldehyde to isopropylate an amine?
Tet. Lett. 3, 261 1973. B. L. Sondengam
Formaline (35%, 35 mmol) was added with stirring to a solution of holafébrine
(prim. amine) 3 mmol in methanol (10 ml) and the solution was refluxed for
30 min. After cooling 400 mg NaBH4 was added slowly. After 1 h the reaction was
evaporated and the mixture was extracted with CHCl2. Evaporation yields iréhine
(dimethyl-holafébrine, 85%).
I bow down to your exquisitely manicured toenails in advance. thankyou