5-HTP --> 5-AcO-T?

[tryptych]

From usenet:

"with dosages of upto 3grams of 5-acetoxy-tryptophan
(acetic acid reacted with 5-htp) interesting deleriant type effects occur"

2 questions:

1. Is this a valid synth? The guy refers somewhat vaguely to simply mixing his 5-HTP with household vinegar and getting 5-Acetoxy-Tryptophan.

2. 3 grams is a lot. Would one also get deleriant effects with 3 grams of straight 5-HTP, or is there reason to believe that doing this conversion would change the nature of the experience.

Sorry.... it's probably a stupid question but if anyone is nice enough to give an answer to this humble wannaBEE that would be appreciated.

[yellium]

deleriant effects are *not* interesting.

Jeeez.



Hardcore libertarians consider the idea of a Libertarian Party dangerously socialist.

[tryptych]

Well the guy posting on Usenet said the visuals were pretty good, with a bit of a scopolamine like feeling... I'm not sure if he knew the difference between deleriants and hallucinogens. I can't see how a compound with this structure would be a true deleriant anyhow. I just want to know if the synth is viable... I will then research it Shulgin style and report back to ya'll.

[MarleyBob]

...maybe interesting but certainly not desirable...

[yellium]

1) Everything Posted On Usenet Is True.

2) As everyone can see on erowid, scopolamine is not exactly a fun drug.

3) High dosages of 2ct7 are also deleriant. And also, not very much fun; not for you, and not for the paramedics. Look up a few high dosage 2ct7 reports to find out more.

Of course, you don't need to be deterred by this from synthing & trying this compound.



Hardcore libertarians consider the idea of a Libertarian Party dangerously socialist.

[Lilienthal]

Sounds like a bad joke. The 5-O-acetyl group will be hydrolyzed in seconds by serum esterases. The only possible effect could be an enhanced brain penetration as the more lipophilic acetylated compound, but 5-hydroxy-tryptophan doesn't really have problems to enterthe brain because it is actively transported into the brain afaik.

[tryptych]

I have been in email contact with the guy, and he seems to be for real... he is claiming effects on the order of being sucked into a black hole with 100mg of the stuff... Unless this is another "bananadine"... I've decided to do the research and see what happens.

I now have a procedure...

Dissolve an amount of 5-HTP in a molar excess of Acetic Acid.

Leave it to sit for 3-4 weeks.

Evaporate and consume.

We will see... it's worth a shot as it's even easier than making GHB from GBL.

Oh, and he is suggesting that the acetylation may be occuring somewhere else as well as at the 5-position... he suggests trying it with acetic anhydride as well and comparing the products.

[yellium]

So? if you look up the effects of a massive 5htp dose, you'll also find 'delerium'.

Hardcore libertarians consider the idea of a Libertarian Party dangerously socialist.

[Lilienthal]

Hehe, let it sit with acetic acid... Forget it! This doesn't work.