Out of all the phenylcyclohexylamine patents I've read, they only use two methods to create cyclohexylideneamine Schiff bases; Distilling off the water from amine/cyclohexanone which is in a solvent with or without the aid of p-tosic acid, or letting the amine/cyclohexanone sit with Na or K hydroxide. Examples are in GB861350, GB836083, US3145229, GB837747, etc.. My question is why don't I ever read about anhydrous Mg-sulfate being used to produce cyclohexylideneamines? Are the yields somehow not as good, is a hydroxide cheaper, or is Mg-sulfate not as fast at absorbing water? Refluxing the shit out of cyclohexanone/amine for several hours is a pain in the ass. The hydroxide method is cool, but wouldn't it be nice if evil chemists didn't have to fart around with the caustic component - and that's why I brought up the idea of Mg-sulfate. Has anyone come across methods unlike the ones I mentioned?
Btw, does anyone know anything about the pharmacology of BENZYL-cyclohexylamines. Have compounds like this been tested in animals/humans? I'm asking because it's easier to make a Grignard from benzyl chloride than it is with bromobenzene.
I better get off my PC before I blabber even more. - Been taking large amounts of neurontin.
Peace!
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