The Hive => Novel Discourse => Topic started by: Alphabeta121 on August 02, 2000, 02:27:00 AM
Title: Flouro Compounds
Post by: Alphabeta121 on August 02, 2000, 02:27:00 AM
This isn't really kitchen chem compatable, but I'm wondering about flourination of desirable compounds, yeilding things like DO(triflouromethyl), 2C-(triflouromethyl), and 3,5 dimethoxy 4- triflouromethyl phenethylamine and phenisopropyl amine. for 2C-TF would one could a vilsmeyer rxn be performed on 2,5 dimethoxy 1 TFM benzene? Or would the TFM group be too electron withdrawing. Or perhaps start with 2 TFM hydroquinone in a basic solution, and do an ortho formylation, then methylate. I've only seen two halogenation reactions, replacement of halogen by KF/ 18- Crown-6 ether, and replacement of a diazonium salt by flouboric acid. Neither of those seem very applicable. Any help or even interest in this topic?
try www.flourosolutions.com and ask the from a business account.
alphabeta121
Title: Re: Flouro Compounds
Post by: Alphabeta121 on August 03, 2000, 06:59:00 AM
have the hive's world famous geniuses all died?
Title: Re: Flouro Compounds
Post by: Rhodium on August 03, 2000, 10:38:00 PM
I have tried a knoevenagel reaction with trifluoromethylbenzaldehyde. The yield was dismal in several attempts, and the starting aldehyde very expensive.
Title: Re: Flouro Compounds
Post by: Alphabeta121 on August 04, 2000, 05:46:00 AM
boner, so I guess that leaves a substituted acetonitrile reduction ala G_Pig? Sounds alright to me, but its the synthesis of the aldehyde that I'm interested in.