None of the patents could bee found with TFSE, nor any related reaction......
Patent GB1493941 (http://l2.espacenet.com/dips/viewer?PN=GB1493941&CY=gb&LG=en&DB=EPD)
Equivalents:
Patent BE824022 (http://l2.espacenet.com/dips/viewer?PN=BE824022&CY=gb&LG=en&DB=EPD)
Patent CH625218 (http://l2.espacenet.com/dips/viewer?PN=CH625218&CY=gb&LG=en&DB=EPD)
Patent DE2435365 (http://l2.espacenet.com/dips/viewer?PN=DE2435365&CY=gb&LG=en&DB=EPD)
Patent FR2255897 (http://l2.espacenet.com/dips/viewer?PN=FR2255897&CY=gb&LG=en&DB=EPD)
Patent JP5009656 (http://l2.espacenet.com/dips/viewer?PN=JP5009656&CY=gb&LG=en&DB=EPD)
Patent NL7417046 (http://l2.espacenet.com/dips/viewer?PN=NL7417046&CY=gb&LG=en&DB=EPD)
Patent ZA7408264 (http://l2.espacenet.com/dips/viewer?PN=ZA7408264&CY=gb&LG=en&DB=EPD)
Abstract: N-Acetyl-5-methoxy-tryptamine is obtained, starting from indigo, by the following reactions:
(a) dry distillation of indigo mixed with zinc powder, to obtain indole;
(b) conversion of the indole to 5-hydroxy-indole by treating the former with methanol in water and in the presence of ferric chloride;
(c) converting the 5-hydroxy-indole to 3-(2-aminoethyl)-5-hydroxy-indole by treatment of the former with 2-amino-1-chloroethane in the presence of ethyl acetate and iron filings;
(d) treating the product obtained from item (c) with dimethyl sulphate at a temperature not exceeding 25 DEG C; and
(e) treating the (2-aminoethyl)-5-oxymethyl-indole, obtained under (d), with acetyl chloride at a temperature not exceeding 10 DEG C.
The novel compound obtained is effective in the treatment of leucoses in their various forms. Its action can be boosted if it is used in combination with one of its derivatives, such as 5-methoxy-tryptamine, 3-(2-aminoethyl)-5-methoxyindole and 5-hydroxyacetyl-tryptamine.
This seems to bee to easy to bee true. Indigo is cheap and OTC, zinc powder too and if you skip the oxidation it could bee possible to directly introduce the dimethylaminoethyl-sidechain of DMT to indole (N-(2-chloroethyl)-N,N-dimethylammoniumchloride is commercially available, cheap but toxic). This would be the cheapest imaginable DMT synth and almost OTC. ::)