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The Hive => Novel Discourse => Topic started by: Chemical_brain on April 17, 2001, 07:17:00 AM

Title: Help to make 1,5-dibromopentane (Method). for PCP
Post by: Chemical_brain on April 17, 2001, 07:17:00 AM

magnesium organometallicderivative of 1,5-dibromopentane
gives PCP. The only difficulty in this route is the preparation of
the dibromopentane Grignard reagent,
Reaction of N-benzoylpiperidine with the lithium or magnesium
organometallic derivative of 1,5-dibromopentane gives PCP. The only difficulty in this route
is the preparation of the dibromopentane Grignard reagent, with its strict requirement for
anhydrous conditions (Method ????).

Title: Re: Help to make 1,5-dibromopentane (Method). for PCP
Post by: Rhodium on April 17, 2001, 02:35:00 PM

Ring opening of tetrahydropyran with HBr, or bromination of 1,5-pentanediol with HBr (or red P + Br2).

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Title: Re: Help to make 1,5-dibromopentane (Method). for PCP
Post by: Chemical_brain on April 21, 2001, 08:01:00 AM

It is possible something more About red P+Br2  and TGF+HBr
the description of process.

Title: Re: Help to make 1,5-dibromopentane (Method). for PCP
Post by: Rhodium on April 21, 2001, 02:46:00 PM

Check out www.orgsyn.org - there should be several ether and alcohol brominations in Organic Synthesis.

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