Author Topic: How do you condense a halide with a methyl ester?  (Read 1544 times)

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bottleneck

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How do you condense a halide with a methyl ester?
« on: October 01, 2002, 12:40:00 PM »
Regarding the SynGen proposed syntheses of lysergic acid from abrine, I presume "E" stands for "ester"?

In route G6, they condense 2,3-dihalopropionic acid and a methyl ester.

http://syngen2.chem.brandeis.edu/sample-output/lysergic_G6.html



For example with methyl acetate, I guess the product should then be 2-(acetoxymethyl)-3-halopropionic acid.

Can anyone tell me which reaction would substitute a halo group with the methyl group of a methyl ester in this manner?