2-Amino-5-substituted oxazolines and intermediates as potential anorectants.Freiter, Edward R.; Abdallah, Abdulmunien H.; Strycker, Stanley J.
Journal of Medicinal Chemistry 16(5), 510-12 (1973)
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https://www.thevespiary.org/rhodium/Rhodium/pdf/2-amino-5-arylthiomethyloxazolines.pdf)
CAN 79:61392, AN 1973:461392
Abstract2-Amino-5-arylthiomethyl-2-oxazolines and their intermediates 1-amino-3-arylthio-2-propanols showed significant anorectant activity but were less active than d-amphetamine. The most active compd. in the series was 2-amino-5-(phenylthiomethyl)-2-oxazoline (I) [41136-03-2], which at 46 mg/kg orally decreased food intake by mice by 62% in the 1st hr after administration. To synthesize I, thiophenol [108-98-5] was reacted with epichlorohydrin [106-89-8] in the presence of NaOH, and the resulting epoxide was reacted with NH
3 to yield 1-amino-3-phenylthio-2-propanol [35550-43-7], which was reacted the CNBr and cyclized to I.