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This article on how to prepare MDP2P from Bromosafrole was posted by lugh a long time ago, but nobody seemed to grasp its significance. The yield is up to 90%, and the needed reagent is 2-nitropropane, which is not watched and also dirt cheap ($15/kg).
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000379066-file_o3et.gif)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/halide.carbonyl.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/halide.carbonyl.html)
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But bee aware that 2-nitropropan is extremly carcinogenic.
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2-nitropropene should neither be an impurity in the starting material or a product in the reaction. Do you have a different opinion?
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But Rhodium is talking about 2-nitropropane, not 2-nitropropene.
Catalytic hydrogenation freak
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It was just ment as a general warning. Nito- methane, ethane and propane is almost non toxic, but 2-nitropropan is for some reason werry caracinogenic. So you have to doo the condensation with the aldehyde with much more care than usual, that's all. Nice synth by the way.