I dont think you would want to defat until you have your acidic extract first. However, if a large amount of plant material is to bee used, a soxhlet would bee excellent for doing a simple methanolic pull (which could then bee vapped resulting in a tar).
Either way, your gonna want to make sure the crap is in acidic conditions first before defatting.
Wouldnt want to throw away the tub with the washwater!
It seems to me that it would bee most efficient to remove the bulk/roughage first, THEN defat. Trying to defat whole plant matter without removing alkaloids- think of all the tannins resin wax etc that is attached to the fibers, youd bee at it for weeks.
Grind the snot out of it (really important for higher yeilds), then multiple freeze/thaw to fracture the cell walls.
Then MeOH extract w/soxhlet (only reccomended if going large scale) then vap the MeOH. Acidify, filter, filter, filter, defat etc...
Histrionic: High
Narcissistic: High