The Vespiary
The Hive => Methods Discourse => Topic started by: wolff_kishner on July 23, 2004, 01:35:00 PM
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Is chlorine an acceptable substitute for bromine in the following syntheses?
1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis)
2. alpha bromination of propiophenone (PPA synthesis from propiophenone)
The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required?
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That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia.
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It might work using a pressure bomb, though.