The Vespiary

The Hive => Methods Discourse => Topic started by: wolff_kishner on July 23, 2004, 01:35:00 PM

Title: Chlorine instead of Br in Ketamine and PPA Synths
Post by: wolff_kishner on July 23, 2004, 01:35:00 PM
Is chlorine an acceptable substitute for bromine in the following syntheses?

1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis)

2. alpha bromination of propiophenone (PPA synthesis from propiophenone)

The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required?
Title: I would imagine
Post by: starlight on July 23, 2004, 03:36:00 PM
That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia.
Title: It might work using a pressure bomb, though.
Post by: Organikum on July 23, 2004, 09:04:00 PM
It might work using a pressure bomb, though.