What's up?! In Patent US2765315 (http://l2.espacenet.com/dips/viewer?PN=US2765315&CY=gb&LG=en&DB=EPD)
(Preparation Of Esters):
"Our process comprises reacting a-methylstyrene, a-ethylstyrene, isobutylene, or 2-methyl-1-butene with a N,N',N"-trimethylhexahydro-1,3,5-triazine and a monocarboxylic acid of the formula R'COOH, where R' is an alkyl group, particularly an alkyl group of not over two carbon atoms. These three reactants are mixed and the mixture is heated between 80* and 125*C.."
I've heard a lot about the production of 1-methyl-4-phenyl-4-acetoxypiperidine from a-methylstyrene, but what about synthing an active analgesic from 2-methyl-1-butene instead? The patent lists it as a suitable precursor, but doesn't use it in any of their examples.. Guess I have two questions; Would product made from 2-methyl-1-butene be active, or are the folks in the patent full of shit? Any references that use the above precursor? Peace! 8)
https://www.thevespiary.org/rhodium/Rhodium/pdf/pethidine.reverse.esters.pdf (https://www.thevespiary.org/rhodium/Rhodium/pdf/pethidine.reverse.esters.pdf)
Hmm ... It is always nice to see people starting their own threads ... Post 438017 (https://www.thevespiary.org/talk/index.php?topic=12260.msg43801700#msg43801700)
(pHarmacist: "Prodine Derivatives (iR spectrum included)", Novel Discourse), so that the information isn't scattered around all over the place (grinch) >:( . Or is Bwiti 's thread not good enough for you? Well, it was JOC after all.
Mabey you could post JOC (1947) p 911 Piperidine derivatives. V. 1,3-dialkyl-4-aryl-4-acyloxypiperidines. Albert Ziering, John Lee in another thread too (preferably in yet another forum)? >:( >:(
Why dont you take a subscribtion on this magazine http://www.asshole.org/ (http://www.asshole.org/)
? >:(
Apothecarius, transite ad inferos (i.e. pharmacist go to hell, in case you are a dumb motherfucker who hasn't got a classical education).
If this is the way thing are going here, I post my future messages WITHOUT REFERENCES. In case I haven't made myself clear, you got me upset -big time >:( . It isn't the first time this shit happened: Post 436680 (https://www.thevespiary.org/talk/index.php?topic=12565.msg43668000#msg43668000)
(Megatherium: "Somebody typed his ass of some time ago on...", Serious Chemistry)
Canis latrans semper mordet in cauda apothecarii :P
Well, I 'm sure you saw the alpha-ethylstyrene synthesis Rhodium posted: Post 432214 (https://www.thevespiary.org/talk/index.php?topic=9806.msg43221400#msg43221400)
(Rhodium: "Wittig Synthesis of alpha-Ethylstyrene", Methods Discourse). Propiophenone is a rather common chemical. n-BuLi might bee harder to get (and it is more difficult to handle, since it requires abslolute dry conditions - no shit - and a nitrogen atmosphere). And BTW, the patent is the only way to go to get an injectable compound (i.e. don't screw around with the piperidone route like in that .PDF article ... or bad things are likely to happen to the substantia nigra of your brain).