Author Topic: New Route to DMT  (Read 4042 times)

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New Route to DMT
« on: November 01, 2001, 09:08:00 PM »
Would a French speaking Bee, bee so kind as to get this article and translate it.  If necessary I can probably get it and scan it, however I don't have easy access to a scanner.

They prepare DMT and 5-meoDMT in this article.

New route to tryptamines.    
Julia, Marc; Bagot, Jean; Siffert, Odile.     
Bull. Soc. Chim. Fr.  (1973),   (4)(Pt. 2),  1424-6.  
Journal  written in French.    

The Mannich reaction of ClCH2CHO with indoles in the presence of NHR32 gave gramines I (R = H, Me; NR32 = NMe2 morpholino; R3 = H, MeO) which were reduced by NaBH4 to the corresponding tryptamines II.  Hydrolysis of I gave the amino alcs. which also rearranged to the a-hydroxytryptamines; dimerization during hydrolysis was also obsd.  Treating II with addnl. ClCH2CHO gave tetrahydrocarbolines III (Q = CHCH2X, X = Cl, OH, H, SO2C6H4Me-p) by a Pictet-Spengler condensation.  Redn. with NaBH4 gave the azepinoindole III (Q = CH2CH2). 

Edit: The article has been translated in

Post 380306

(Chimimanie: "New route to DMT & 5-MeO-DMT", Tryptamine Chemistry)

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