Author Topic: Microwave synthesis of Melatonin  (Read 2894 times)

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Rhodium

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Microwave synthesis of Melatonin
« on: May 11, 2003, 08:26:00 PM »
Microwave Assisted Synthesis of Melatonin

Synthetic Communications Vol. 33, No. 5, pp. 741–747 (2003)

(https://www.thevespiary.org/rhodium/Rhodium/pdf/melatonin.microwave.pdf)

Abstract

Melatonin was prepared from phthalimide by N- and C-alkylation, cyclization, hydrolytic, decarboxylation, and acetylation. The four-pot reactions were carried out on microwave irradiation in good yield with short time.

Greensnake

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Ok, could anybody explain reaction step from 2
« Reply #1 on: May 12, 2003, 08:54:00 PM »
Ok, could anybody explain reaction step from 2 to 3, something rather fishy there. (I would believe in Japp-Klingeman reaction , but then it use diazonium salt, not arylhydrazine - yet another example of "not very accurate" research paper?)