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Articles on ergot cultivation

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bottleneck:
It has been suggested that some of these articles might be useful for some people. They'll stay online a couple of weeks for those who want them.



Lloydia;1962;25;37-45;Pacifici et al;Production of Lysergic Acid Derivatives in Submerged Culture.  I. Fermentation Studies. (http://www.geocities.com/botero56/Lloydia.1962.25.37-45.Pacifici_et_al.pdf)

Lloydia;1962;25;161-73;Pacifici et al;Production of Lysergic Acid Derivatives in Submerged Culture.  II. Strain Selection and Screening. (http://www.geocities.com/botero56/Lloydia.1962.25.161-73.Pacifici_et_al.pdf)

Lloydia;1963;26;174-91;Gröger & Tyler;Alkaloid Production by Claviceps paspali in Submerged Culture. (http://www.geocities.com/botero56/Lloydia.1963.26.174-91.Groeger_Tyler.pdf)

Adv. Appl. Microbiol.;1969;11;211-44;W.J. Kelleher;Ergot Alkaloid Fermentations. (http://www.geocities.com/botero56/AdvApplMicrobiol.1969.11.211-44.Kelleher.pdf)

wyndowlicker:
Thanks that just what I was looking for.  :P

silenziox:
Bhankzzz you :)

According to one of those papers - and I quote -

"(Pacifici et al., 1962; Gröger and Tylet, 1936). Kobel
et al. (1964) then described an isolate of C. paspali which
produced high yields of delta-8,9 lysergic acid in submerged
culture. This product is readily converted to delta-9,10
lysergic acid by heating with dilute aqueous alkali"

the delta-8,9 lysergic acid must be paspalic acid
(we all know the conversion which has been posted on this
forum and which can also be found at rhodium.ws).

There are 3 different Delta-8,9's there:
Agroclavine, Elymoclavine and Molliclavine...
Molliclavine looks suspicious.
http://www.tacethno.com/info/claviceps/ergotalkfungi.txt, C. paspali submerged cultures have ergine,
isoergine and lysergic acid N-1-hydroxyethylamide (Arcamone
et al., 1960) while sclerotia from Australia contain up to
0.005% alkaloids composed of ergine and ergonovine along
with chanoclavine and two unidentified ergoline alkaloids
(Groger et al., 1961). Elymoclavine (Kobel et al., 1964)
and agroclavine (Brar et al.,1968) have also been recorded.

at http://www.kav.cas.cz/pdsb/OR8/SKOLITEL8.html
there is something about Flieger M., Sedmera P., Havlíèek V., Cvak L. Stuchlík J.: 10-OH cis and 10-OH trans paspalic acid amide - new alkaloid of Claviceps paspali.

Anybee got Journal of Natural products, 56 [6] 810-814 (1993)??

Now, SWIM is still only interested of paspalic acid and
wants to know how only (~95%) it can be produced

Or is everything extracted out from C. paspali regarded
as paspalic acid???

Anybee?

flipper:
Patents

US2056360 (http://l2.espacenet.com/espacenet/viewer?PN=US2056360&CY=gb&LG=en&DB=EPD)
GB755555 (http://l2.espacenet.com/espacenet/viewer?PN=GB755555&CY=gb&LG=en&DB=EPD)
US2809920 (http://l2.espacenet.com/espacenet/viewer?PN=US2809920&CY=gb&LG=en&DB=EPD)
US2835675 (http://l2.espacenet.com/espacenet/viewer?PN=US2835675&CY=gb&LG=en&DB=EPD)
GB837423 (http://l2.espacenet.com/espacenet/viewer?PN=GB837423&CY=gb&LG=en&DB=EPD)
US2936266 (http://l2.espacenet.com/espacenet/viewer?PN=US2936266&CY=gb&LG=en&DB=EPD)
GB883329 (http://l2.espacenet.com/espacenet/viewer?PN=GB883329&CY=gb&LG=en&DB=EPD)
US3038840 (http://l2.espacenet.com/espacenet/viewer?PN=US3038840&CY=gb&LG=en&DB=EPD)
US3060104 (http://l2.espacenet.com/espacenet/viewer?PN=US3060104&CY=gb&LG=en&DB=EPD)
US3110651 (http://l2.espacenet.com/espacenet/viewer?PN=US3110651&CY=gb&LG=en&DB=EPD)
GB993982 (http://l2.espacenet.com/espacenet/viewer?PN=GB993982&CY=gb&LG=en&DB=EPD)
GB1064764 (http://l2.espacenet.com/espacenet/viewer?PN=GB1064764&CY=gb&LG=en&DB=EPD)
US3219545 (http://l2.espacenet.com/espacenet/viewer?PN=US3219545&CY=gb&LG=en&DB=EPD)
US3276972 (http://l2.espacenet.com/espacenet/viewer?PN=US3276972&CY=gb&LG=en&DB=EPD)
US3282796 (http://l2.espacenet.com/espacenet/viewer?PN=US3282796&CY=gb&LG=en&DB=EPD)
GB1170600 (http://l2.espacenet.com/espacenet/viewer?PN=GB1170600&CY=gb&LG=en&DB=EPD)
US3884762 (http://l2.espacenet.com/espacenet/viewer?PN=US3884762&CY=gb&LG=en&DB=EPD)

Well I deserve a big excellent for this.

If there are more beautiful patents on the subject, please post them. Thanks.  :)

Bubbleplate:
You're the MAN! These will help so much in my fermentation research and experiments!
All you Bio-Bees out there: let's take the info Bottleneck and others have provided here and run with it. Setting up a fermenter isn't that hard, and once we find a good Lysergic producing strain, we can pass it around and share it. Growing a fungus in a culture medium is much easier than synthing some some chemicals together. Let's DO IT!

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