From the Merck Index:
Monograph number: 6772
Title: Nonoxynol.
CAS Registry number: [26027-38-3]
CA name(s): .alpha.-(4-Nonylphenyl)-.omega.-hydroxypoly(oxy-1,2-ethanediyl); polyethyleneglycols mono(nonylphenyl) ether;
Additional name(s): macrogol nonylphenyl ether; nonoxinol; polyoxyethylene(n)nonylphenyl ether; nonylphenyl polyethyleneglycol ether;
nonylphenoxypolyethoxyethanol.
Literature references: Nonionic surfactant mixtures prepd by reacting nonylphenol with ethylene oxide. Prepn of polyoxyethylated alkyl phenols: A. Steindorff et
al., U.S. pat. 2,213,477 (1940 to GAF). Average number of ethylene oxide units (n) per molecule is indicated by number following nonoxynol (e.g. nonoxynol-15 for n
= 15). Trademarks for nonoxynol series include Conco NIContinental Chem., Dowfax 9NDow, Igepal CORhone-Poulenc, Makon, Neutronyx 600'sOnyx, Nonipol
NOSankyo, Polytergent BOlin, Renex 600'sAtlas, Solar NPSwift, SteroxMonsanto, Surfonic NJefferson, T-DET-NThompson-Hayward, Tergitol NPUnion Carbide,
Triton NRohm Haas. Individual members of series indicated by numerical suffixes. Toxicology study: H. F. Smyth Jr., J. C. Calandra, Toxicol. Appl.
Pharmacol. 14, 315 (1969). Inactivation of HIV in vitro by nonoxynol-9: M. Malkovsky et al., Lancet 1, 645 (1988). Clinical evaluation of nonoxynol-9 in sexually
transmitted diseases: W. C. Louv et al., J. Infect. Dis. 158, 518 (1988). Review: C. R. Enyeart, "Polyoxyethylene Alkylphenols" in Nonionic Surfactants, M. J.
Schick, Ed. (Dekker, New York, 1967) pp 44-85.
Properties: Highly stable compounds. Lower adducts (n <15) are yellow to almost colorless liquids; higher adducts (n >20) are pale yellow to off-white pastes or
waxes. Lower adducts (n <6) sol in oil; higher ones sol in water. Review of physical properties: Enyeart, loc. cit.
Derivative: Nonoxynol-9
Trade name(s): C-Film (Arun), Conco NI-90 (Continental Chem.), Dowfax 9N9 (Dow), Encare (Norwich), Gynol II (Ortho-Cilag), Igepal CO-630 (Rhone-Poulenc),
Intercept (Ortho), Neutronyx 611 (Onyx), Semicid (Am. Home), Staycept (Syntex), Tergitol TP-9 (Union Carbide).
Properties: av. mol wt 617. A component of ConceptrolOrtho, DelfenOrtho, GentersalOrtho, Ortho-cremeOrtho. Almost colorless liquid. For Igepal CO-630: d425
1.06; solidif pt 26 +/-2 degF; pour point 37+/-2 degF; flash point: 535-555 degF; cloud point (1% aq soln) 126-133 degF; viscosity (25 deg) 175-250 cp. Sol in water, ethanol, ethylene
glycol, ethylene dichloride, xylene, corn oil. Insoluble in Stoddard solvent, deodorized kerosene, low viscosity white mineral oil.
Density: 1.06
Derivative: Nonoxynol-11
Trade name(s): Duragel (LRC), Duracreme (LRC).
USE: Nonionic surfactants used as detergents, emulsifiers, wetting agents, dispersants, stabilizers, intermediates in synthesis of anionic surfactants, defoaming agents.
Nonoxynols-9, 11 as spermaticide. Nonoxynols-4, 15, 30 as pharmaceutic aids (surfactants).
