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Post 28888 (missing)
Iff the HCl salt is soluble in the AcOH (I don't think it is, the HBr of 2-cb is not) then it's posible,
Is there any reason why the 2CH couldn't be dissolved in a minimal amount of H2O and added to the HOAc/Br2? SWIM understands that the 2CB HBr is soluble in H2O and won't crystalize upon formation, but is there any reason why the post-rxn mixture couldn't be washed with DCM to remove excess bromine and then acid/based as usual? Perhaps the only drawback being extra NaOH needed to neutralize the HOAc.
but why bother, the Shulgin way works greath.
SWIM has no doubt that it does, but in these dreams the 2CH is already in the HCl salt form (it had to be stored for an extended period of time, forming the HCl salt seemed the most convienient way for this). If basifying/extracting/removing solvent pior to brominating can be skipped, that would be nice.SpicyBrown