The Vespiary

The Hive => Tryptamine Chemistry => Topic started by: Bandil on October 18, 2001, 02:05:00 AM

Title: Column chromatography of psilocybin!
Post by: Bandil on October 18, 2001, 02:05:00 AM

Hi!

Swim was thinking it would be really cool to have >95% pure psilocybin crystals lying around, as they are quite pretty. Now the mushrooms contain a lot of different alkaloids, that are quire hard(impossible) to separate, by simpel A/B. What about column chromatography:

1) Is silica gel ok for the column?
2) What to use as eluent, DCM, EtOAcOH?
3) I suppose one would have to apply strong vac underneath the column?
4) How to figure out what fractions the psilocybin is in. I was thinking of some TLC(NMR is not an option)

Thanks!

Regards
Peter

Title: Re: Column chromatography of psilocybin!
Post by: Rhodium on October 18, 2001, 02:07:00 AM

https://www.thevespiary.org/rhodium/Rhodium/chemistry/psilo-tlc.txt (https://www.thevespiary.org/rhodium/Rhodium/chemistry/psilo-tlc.txt)

Title: Re: Column chromatography of psilocybin!
Post by: lugh on October 18, 2001, 08:04:00 AM

And

Post 176035 (https://www.thevespiary.org/talk/index.php?topic=13041.msg17603500#msg17603500)

(lugh: "Re: psilocin", Tryptamine Chemistry)  :)