The Vespiary

The Hive => Serious Chemistry => Topic started by: malvaxman on November 09, 2001, 02:23:00 AM

Title: L-PAC from benzaldehyde with pyruvatedecarboxylase
Post by: malvaxman on November 09, 2001, 02:23:00 AM

L-PAC is possible to make from benzaldehyde with torula-yeast has anyone seen any outline to do it without yeast with pyruvatedecarboxylase? Is PDC easy to get and how much does it cost?

Title: pyruvatedecarboxylase
Post by: Organikum on April 29, 2002, 03:45:00 PM

The production of L-PAC by the enzymes directly was mentioned in some australian patents as far as I remember. It was told to be quite effective but expensive and not to easy as some coenzymes are needed or a real huge amount of pyruvatedecarboxylase.
It seems that starting with pyruvic acid and yeast is state of the art. Pyruvic acid is not real cheap (~400€ kg if bought by tons) and only OTC if bought as wellness product (expensive then). But it can be made by the pyrolyse of tataric acid. And on a biosynthetic pathway of course.

Patent DE3733157 (http://l2.espacenet.com/dips/viewer?PN=DE3733157&CY=gb&LG=en&DB=EPD)

german

Patent US4971907 (http://l2.espacenet.com/dips/viewer?PN=US4971907&CY=gb&LG=en&DB=EPD)

two for the biopath.

It should be possible to add acetaldehyde instead pyruvic acid, but I have not been in this deeper so I cannot tell pros and cons.



so far
ORGY