Sirs, all of you heard about tiletamine and as it make too know, but there is one nuance, - how to make itself thiophene. Is there anybody know a pair - three methods?
For it in general prepare from disodium succinate and P4S7. Refers to as Volhard-Erdmann cyclization.
Who may find the following references?
It is very necessary.
J. Volhard and H. Erdmann,Ber,18,454(1885)
L. H. Friedburg, J. Am. Chem. Soc. 12, 83 (1890); J. Chem. Soc. 58,1400 (1890)
H. Scheibler and M. Schmidt Ber. 54, 139 (1921)
H. Scheibler and F. Rettig, Ber. 59, 1194 (1926)
R. Phillips, Organic Syntheses coll. vol. II, 578 (1913)
J. C. Pernert and J. H. Brown, Chem. Eng. News 27, 2143 (1949)
F. F. Blicke in R. C. Elderfield, Heterocyciic Compounds 1, 212 (New York, 1950)
D. E. Wolf and K. Folkers in Organic Reactions VI, 412 (1951)
R. F. Feldkamp and B. F. Tullar in Organic Syntheses coll. vol. IV. 671 (1963).