Hi!
I have some questions on the synthesis of 3,4,5-trimethoxybenzaldehyde from 5-Hydroxyvanillin.For this synthesis I need dimethyl sulfate,and I searched the internet and also The Hive archive,but I didn´t find anything about the synthesis of dimethyl sulfate.But in the Rhodium archive there is something about the synthesis of diethyl sulfate from EtOH,H2SO4 and Na2SO4.Is the synthesis of dimethylsulfate analog to it,that I only have to calculate the amount of MeOH?Or has someone a synthesis for 3,4,5-trimethoxybenzaldehyde from 5-hydroxyvanillin in which another methylation agent is used,that ist less toxic and that could be made relatively easy?
And I thought about the synthesis of Syringaldehyde,in which sodium and MeOH are used to make 3,5-dimethoxy-4-hydroxy-benzaldehyde.The bromine ist substituted by a -O-Me group.
Can I make 3,5-dibromo-4-methoxybenzaldehyd from bromine and anisaldehyde and convert it into 3,4,5-trimethoxybenzaldehyde using MeONa?