The Vespiary
The Hive => Chemistry Discourse => Topic started by: blessed on May 26, 2003, 04:36:00 PM
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Is there an easy way to remove tetrabutylammoniumfluoride (TBAF) or other TBA-salts from your rxn-product, in cases where recrystallisation won´t work (other than ion-exchange chromatography)??
This TBA-stuff sticks to my product all the way through extracting, washing, and more than one flash-silicagel-chromatography!
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Which product?
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distillation?
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products = different 1,2-Biphenylacetylenes from two succeesing Sonogashira-rxn with TMS-Acetylen and aromatic iodides
TBAF was used for removal of TMS-Group after first Sonogashira-rxn(destillation seems unprobable, products are crystalline solids)
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Silica gel should remove it. Use the good 200mesh merck stuff. If that doesn't work, (I couldn't tell you why not)
use cation exchange resin.