The Vespiary

The Hive => Chemistry Discourse => Topic started by: xeno_tropic on June 27, 2003, 02:21:00 AM

Title: N-Arylalkyl Piperazine Alylkylation
Post by: xeno_tropic on June 27, 2003, 02:21:00 AM

If I have a piperazine which is heavily alkylated at one nitrogen, such as phenethylpiperazine, could the other nitrogen be alkylated with cyclohexyl bromide and KCO3 in alcohol (+ heat)? Is there anything which stands out as wrong with the idea of this reaction?
Thanks

Title: 1-Phenethyl-4-Cyclohexyl-piperazine
Post by: Rhodium on June 27, 2003, 10:35:00 AM

No, that general idea is sound, and the product would in that case be 1-Phenethyl-4-Cyclohexyl-piperazine. However, you might need to look up the exact reaction specifics (reaction time, amounts, temperature) or be prepared to experiment some for optimum yield.