Author Topic: N-Arylalkyl Piperazine Alylkylation  (Read 1861 times)

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xeno_tropic

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N-Arylalkyl Piperazine Alylkylation
« on: June 27, 2003, 02:21:00 AM »
If I have a piperazine which is heavily alkylated at one nitrogen, such as phenethylpiperazine, could the other nitrogen be alkylated with cyclohexyl bromide and KCO3 in alcohol (+ heat)? Is there anything which stands out as wrong with the idea of this reaction?
Thanks

Rhodium

  • Guest
1-Phenethyl-4-Cyclohexyl-piperazine
« Reply #1 on: June 27, 2003, 10:35:00 AM »
No, that general idea is sound, and the product would in that case be 1-Phenethyl-4-Cyclohexyl-piperazine. However, you might need to look up the exact reaction specifics (reaction time, amounts, temperature) or be prepared to experiment some for optimum yield.