hi, xicori. i have no experience at all with cyclidines, but i am
very interested to hear about PCP analogs. i can only give very
general answers.
> why distill off the solvent?
> to increase reactivity? would it also work without distilling
> off the ether and keeping the mixture @ reflux for about 30 hours?
if the text says that 83° is needed for 16h, then it propably is so.
chances are big that the reaction will take an eternety and a half
at 40°.
> - may there be some danger of peroxide explosion (ether is from
> unopened bottle, about 6 months old) when distilling ooff the Et2O?
utfse on ether peroxides. there's everything you need: detection, destruction
and stabilisation.
> - is there any chance to find the boiling point of N-Benzoylmorpholine
> and the PCPm-freebase - please help here when possible?
beilstein crossfire. maybe someone is so kind?
other remarks:
why not use the tosic acid method? tosic acid is very easy to make.
check fallen_angels method:
Post 389646
(Antoncho: "Toluenesulfonic acid - tips and tricks.", Methods Discourse).
what worked very well for me was cooking until everything was dissolved,
adding a (calculated) minute amount of H2O (turning the whole mass into a
solid), recrystallising twice from conc HCl and drying over NaOH.
i think PCPm is a misnomer. it should be called PCM or PCMo.
(there's no more piperidine in it!)
have you thought about extracting piperidine from pepper?
that should be easy with an improvised soxhlet (or
even without) and i think many bees would profit from a
working pepper --> piperidine procedure.