Some of the biggest finding in this field have been the result of trying to do things that the books or internet say can't happend. For example look at the history of Victor Auguste. His boss said that the idea of the grignard was no big deal, and that it would not amount to anything. And some of the biggest failures are the result of people not learning from other people's failures. Innovation isn't about repeating experiments which didn't work the last time someone tried it out, it is to charter unknown territories where hidden treasures are believed to be found.
We say that we do not believe this reaction can take place, until you show us any proof that it will. You can either dig up a literature reference or perform the experiment yourself and then report back to us. But until you have done either, your postings here are nothing more than a cry for someone to try out your unlikely ideas for you, which will not happen anyway, so you are only wasting our time.
As we all know he was rewarded with noble prize.It's very ignoble to spell the Nobel prize that way.
All those things that you just mention above, say "on the aromtic ring, the Halogen and the amino group is not on the aromtic ring.Incorrect, as #6c contradicts your proposed synthesis. The example shows an alcohol, but amines are almost as reactive.
Also I do think that Active Hydrogen is not like water, Last time I check the pH of that H on the amino group is a lot higher then the H of water.Definitely, the pKa of water is ~15 and that of amines is ~30-35. These values pale in comparison to grignard reagents, which usually approaches a pKa of ~50!
The point here being that I believe it is impossible to form a base with pKa ~50 in the presence of a pKa ~30 amine, so that the RMgX won't form in the first place, and thus cannot quench intramolecularly to give methamphetamine from bromoephedrine.
I would not ask a question like that because that would be dumb, it would be obvious why I would ask that questionIs it an obviously drug-related question to ask your respected mentor if he can present a grignard reaction of a molecule containing both a secondary amine and a halogen? I wouldn't say so.
The question that I asked was just about the active hydrogens interfering with grignard, he responded with an ester and proceeded to show me that it could be done with the above information that I have already stated.What ester, and with which pKa?
The Mg is a lewis baseNo.
http://dbhs.wvusd.k12.ca.us/AcidBase/Intro-to-Lewis-AcidBase.html
and would react with the strongest lewis acid. In this case assuming that everything is dry will react with the group that is the strongest base, either NH or -Br. No, Grignard reagent formation is not about simple acid/base chemistry. The reaction RX + Mg -> RMgX is radical in nature, but the precise mechanism has not yet been elucidated. DOI:
10.1333/s00897030725a