The Vespiary

The Hive => Novel Discourse => Topic started by: pROcon on May 25, 2002, 01:03:00 AM

Title: Is Meth a precursor for anything interesting?
Post by: pROcon on May 25, 2002, 01:03:00 AM
I know basically nothin, but ill ask anyway, could a clever bee make anythng nterestng out of methylene amphetamine?

Like could it be used as a precursor to ma-somethn or somethn-ma? :-[
don't call me...I wont answer, or call you back.
Title: meth -> ?
Post by: Rhodium on May 25, 2002, 02:44:00 AM
Nope, it doesn't get any better or worse than meth, unless you are interested in synthesizing L-deprenyl (MAOI and nootropic) by isolating the l-methamphetamine isomer and reacting that with propargyl bromide. But it is much easier and cheaper to buy L-deprenyl over the net.
Title: hehe
Post by: Lilienthal on May 25, 2002, 10:36:00 PM
N-protect, p-nitrate, reduce, m-nitrate, reduce, Sandmeier, O-O-methylenation, N-deprotection  :P
Title: Sounds like more trouble than it`s worth..
Post by: SPISSHAK on May 26, 2002, 12:03:00 AM
what about demethylation of ephedrine to ppa?
What kind of protective groups would you use to protect the alcohol from oxidation to ketones, during oxidative amide formation from the alkylamine.
This might be too much troble too...
Title: Lilienthal - a huge LOL in your direction!
Post by: Antoncho on May 26, 2002, 11:44:00 AM
:)  ;D  :)  ;)  :)  ;D

Yours,

Antoncho
Title: I think I could stir up some serious trouble!
Post by: Ritter on May 26, 2002, 11:32:00 PM
hmmm.  Lets see.  We could definitely make something useful out of that chemical garbage precursor you kids call methamphetamine :P  ;D . 
If we attach a  three carbon chain to the meth. amine group, we have a perfect precursor for an acyclic fentanyl analogue.  That attached carbon chain must of course terminate with a leaving group, preferably bromine in this case.  Now all we have to do is alkylate some aniline with that halogenated compound and acylate the aromatic amine with propionyl chloride.  Aniline can be easily alkylated by employing a Pd salt/ligand catalyst along with  a few equivalents of strong base (K-t-BuO). 

Another synth would start with acylation of the methamphetamine amine with 3-chloropropionyl chloride then alkylate and acylate as mentioned above.  The final step will be reducing the carbonyl group attached to the phenylisopropylamine nitrogen.  The product N-(3 methyl-phenylisopropylamino)-propyl-N'phenyl propionamide appears similar to some structures on this page:

http://www.ch.ic.ac.uk/ectoc/echet98/pub/028/index.htm (http://www.ch.ic.ac.uk/ectoc/echet98/pub/028/index.htm)




So what do you know, turns out that meth isn't completely useless afterall!   :P
Title: hahahahahahaha
Post by: KiZaDm on May 28, 2002, 09:26:00 PM
;)
LYFizBUTaDREAM...and then you wake up dead!