In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines
Leonie Blackburn and Richard J. K. Taylor
Org. Lett. 3(11) 1637-1639 (2001) (https://www.thevespiary.org/rhodium/Rhodium/pdf/alcohol2amine.pscbh.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/alcohol2amine.pscbh.pdf)
DOI:10.1021/ol015819b (http://dx.doi.org/10.1021/ol015819b)
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000484617-file_kdlw.gif)
Abstract
Manganese dioxide is employed as an in situ oxidant for the one-pot conversion of alcohols into imines. In combination with polymersupported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence is reported. This procedure enables alcohols to be converted directly into both secondary and tertiary amines.