Note The article referenced but not posted after searching TFSE no hits for 16 532 1973 with the study , hence with that in mind I post it as it may be of some use to the Hive , thanks to Hyperlab Chemister reference at http://rzv073.rz.tu-bs.de/bib/dir1/Books/booknews.htm (http://rzv073.rz.tu-bs.de/bib/dir1/Books/booknews.htm)
Emetic Activity of Reduced Lysergamides
David g. Teiger; Ronald J. Kassel; Fatima N. Johnson, Istvan E. Ary
Journal of Medicinal ChemistryVol. 16 No. 3 532 1973
Abstract
A new efficient method for the direct amidation of d-lysergic acid was used to prepare a variety of lysergamides. A pharmacological evaluation of these compounds, their di- and tetrahydro derivatives, and derivatives bearing substituents in the indole portion of the molecule showed that, in general, only 9,lOdihydrolysergamides of primary amines possess activity comparable to the potent emetic activity of the components of dihydroergotoxine.
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