Well, you won't have to run a column or anything, but nothing short of an A/B will work.
Glucose and MDMA.HCl have similar physical properties. IIRC, both are insoluble in highly non-polars (hexane, toluene, xylene, etc), soluble in moderate non-polars (EtOAc, DCM), quite soluble in alcohols, extremely soluble in water.