As far as I know, all known di- and trihalogenated amphetamines are virtually inactive in animal tests, as can be seen in the following article which tells us that 2,4-dichloro- and 2,4,5-trichloro-amphetamine may have slight DOM-like activity, but only at dosages which killed 25-75% of the rats...
Structure-Activity Relationships in Psychotomimetic Phenylalkylamines
F. A. B. Aldous, B. C. Barrass, K. Brewster, D. A. Buxton, D. M. Green, R. M. Pinder, P. Rich, M. Skeels, and K. J. Tutt
J. Med. Chem., 1974, Vol. 17, pp. 1100-1111 (1974) (https://www.thevespiary.org/rhodium/Rhodium/pdf/sar.psychotomimetic.phenylalkylamines.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/sar.psychotomimetic.phenylalkylamines.pdf)
Abstract
A study has been made of the relationship between the structure of phenylalkylamines and potential correlates of their psychotomimetic activity. Optimum activity is associated with (a) an isopropylamine side chain, with a R-(-) configuration at the carbon atom a to the amino group, and (b) 2,5-dimethoxy substitution, together with an alkyl or halo group at position 4 that is probably limited in bulk to n-propyl or bromo. The activity of compounds in producing hyperthermia in rabbits provides good quantitative correlation with reported psychotomimetic activities in man.